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(There are other combinations, but I feel like this is the one for extreme cases) You get to fire off a Harpie's Feather Duster + Raigeki on the opponent's turn while gaining 2 card advantage, and since one of the cards added is Virtuous, you are guaranteed to deal with Albazoa, which can withstand Meteor

Similarly, I played a recent game with known glass cannon Neheb, the Eternal

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Niv-Mizzet, Parun Niv Mizzet, Dracogenius The Locust God Ovika, Enigma Goliath Crackling Crackling Zoanthrope Keranos, God of Storms Big Spells What Izzet lacks in big creatures it makes up for in big ideas

Bits of Beast, Arsenal, and (to some extent) Mist can be seen in the Fusions as well